Ready To Ship Gapdh Loading Control Antibody Add To Cart [WbzQxh3p]

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH),also called uracil DNA glycosylase, catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolis.

While GAPDH has long been recognized as  playing an integral role in glycolysis, additional functions of GAPDH include acting as an uracil DNA glycosylase, activating transcription, binding RNA and involvement in nuclear RNA export, DNA replication and DNA repair. Expression of GAPDH is upregulated in liver, lung and prostate cancers. GAPDH translocates to the nucleus during apoptosis. GAPDH complexes with neuronal proteins implicated in human neurodegenerative disorders including the β-Amyloid precursor, Huntingtin and other triplet repeat neuronal disorder proteins.

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