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CK-666: ARP2/3 Inhibitor for Advanced Research

CK-666, also known as ARP2/3 inhibitor (TBI3346), is a cutting-edge research tool designed for scientists seeking to delve into the complex world of actin assembly and its related processes. This potent and selective inhibitor is ideal for studying the ARP2/3 complex, which plays a crucial role in actin nucleation and cell architecture. With its reversible action and high purity (>98%), CK-666 offers a reliable and effective solution for exploring the intricate mechanisms of actin-related processes both in normal and pathophysiological contexts.

Product Specifications and Features

CK-666 boasts a molecular formula of C₁₈H₁₇FN₂O and a formula weight of 296.34. It is available in powder form and is highly soluble in DMSO (up to 45 mg/ml) or Ethanol (up to 30 mg/ml), making it convenient for various experimental setups. The product is stored at -20°C and maintains its stability for over a year, ensuring long-term usability. Key features include its purity, solubility, and storage conditions, which all contribute to its reliability and effectiveness in research applications.

Applications and Benefits

CK-666 is a valuable tool for researchers studying actin assembly and related processes, particularly in the fields of neuroscience and cellular biology. Its ability to block actin nucleation and alter lamellipodial actin architecture offers insights into cell shape, spreading, and the cellular response to various stimuli. For instance, CK-666 has been shown to attenuate BBB dysfunction induced by methamphetamine, making it a significant asset in the study of neurodegenerative diseases. This product is not only a powerful research tool but also a key component in understanding the complex interplay between actin and cellular processes, providing valuable insights for both basic research and potential therapeutic applications.