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Ansatrienin B: A Cytotoxic Powerhouse

Ansatrienin B, also known as Mycotrienin II and Antibiotic T2311, is a potent cytotoxic compound derived from Streptomyces sp. This novel ansamycin exhibits remarkable bioactivity, making it a valuable tool in various research and clinical applications. With its unique molecular structure and high purity (>98%), Ansatrienin B is ideal for in vitro studies and drug development.

• High Purity: Ensures reliable and consistent results in experiments.
• Novel Ansamycin Class: Offers new insights into the mechanisms of action of this class of compounds.

Technical Specifications and Formulation

Ansatrienin B boasts a molecular formula of C₃₆H₅₀N₂O₈ and a formula weight of 638.87. The compound is readily soluble in DMSO, DMF, ethanol, and methanol, allowing for easy handling and storage. It is available in a lyophilized form for convenient reconstitution, and its stability is guaranteed for up to one year when stored at -20°C. These specifications make Ansatrienin B a versatile and reliable choice for researchers and pharmaceutical developers.

• Solubility: Compatible with various solvents for easy use.
• Storage: Stable and long-lasting when stored properly.

Applications and Benefits

Ansatrienin B has been shown to possess significant cytotoxic activity, making it a promising candidate for cancer research and drug discovery. Its ability to inhibit osteoclastic bone resorption and potentiate the activity of antitumor agents highlights its potential in treating various types of cancer. Additionally, Ansatrienin B acts as a translation inhibitor, preventing ICAM-1 expression induced by pro-inflammatory cytokines, which could have implications in the treatment of inflammatory diseases. These diverse applications make Ansatrienin B an invaluable tool for researchers and clinicians seeking innovative solutions in the fight against disease.

• Cancer Research: Potentiates antitumor agents and inhibits osteoclastic bone resorption.
• Inflammatory Diseases: Inhibits ICAM-1 expression for potential therapeutic benefits.