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TG003: Clk Family Kinase Inhibitor

Introducing TG003, a cutting-edge Clk family kinase inhibitor that is poised to revolutionize research in molecular biology and pharmacology. This potent ATP-competitive inhibitor is designed to target and suppress the activity of Clk-family kinases, making it an invaluable tool for scientists seeking to understand the complex mechanisms of cell signaling and gene expression.

• High Purity: With a purity of greater than 98%, TG003 ensures reliable and consistent results in your experiments.
• Stable Formulation: Available as a powder, TG003 is easy to handle and store, providing convenience and flexibility in your research protocols.

Key Features and Specifications

TG003 boasts a unique molecular formula, C₁₃H₁₅NO₂S, and a formula weight of 249.33. It is identified by the CAS number 719277-26-6 and is highly soluble in DMSO and ethanol, making it adaptable to various experimental conditions. With a storage temperature of -20°C and a stability of over two years, TG003 is a reliable choice for long-term research studies.

• Specificity: TG003 effectively inhibits Clk-family kinases, including mClk4, 1, and 2, with IC50s of 15, 20, and 200 nM, respectively, while exhibiting no activity against mClk3 at concentrations greater than 10 μM.
• Multiple Applications: This inhibitor also demonstrates efficacy against DYRK1A/B with IC50s of 24 and 34 nM, making it a versatile tool for a wide range of research applications.

Applications and Benefits

TG003 is a powerful tool for studying the regulation of alternative splicing and the phosphorylation of serine/arginine-rich proteins in mammalian cells. By inhibiting Clk1/Sty-dependent alternative splicing, TG003 can promote the skipping of exon 31 in the endogenous dystrophin gene and increase levels of Clk1/4 mature mRNAs by promoting splicing of intron-retaining RNAs.

• Research Advancement: This inhibitor can accelerate your research by providing a means to manipulate gene expression and study the effects of Clk-family kinases on cellular processes.
• Applications: Ideal for use in cell-based assays, biochemical studies, and in vitro experiments, TG003 is a valuable asset for any laboratory focused on understanding cell signaling and gene regulation.