Genius Solution Formoterol Hemifumarate, β2-adrenergic Agonist, Potent And Selective (tbi5092) Collection [MxNJw0SW]

Superior β2-Adrenergic Agonist for Respiratory Health

Introducing Formoterol hemifumarate, a potent and selective β2-adrenergic agonist designed to address respiratory diseases effectively. This innovative compound is known for its rapid and sustained action, making it an invaluable tool in the management of conditions such as asthma and chronic obstructive pulmonary disease (COPD). With its unique ability to target β2 receptors specifically, Formoterol hemifumarate offers precise therapeutic benefits without interfering with other adrenergic receptors. Its potent and selective action is highlighted by its Ki value of 7.6 nM for β2 receptors and over 2.6 µM for β1 receptors, ensuring maximum efficacy with minimal side effects.

Product Specifications and Formulation

Formoterol hemifumarate, also known as BD 40A, is available in high purity (>99%) and presented as a powder for convenience. Its molecular formula is C₁₉H₂₄N₂O₄ • ½C₄H₄O₄, with a formula weight of 402.50. This product is highly soluble in DMSO, allowing for easy dilution in aqueous buffers. With a storage temperature of room temperature (RT) and stability of over 2 years, Formoterol hemifumarate offers reliable performance and long-term storage capabilities. Key features include its rapid solubility in DMSO (up to 20 mg/ml) and the ability to be stored at -20°C for up to 3 months without degradation.

Applications and Benefits

Formoterol hemifumarate's versatile applications make it a valuable asset in various therapeutic scenarios. Its potent, long-acting agonist properties reduce adhesion and superoxide anion production in activated eosinophils, offering relief in respiratory conditions. Moreover, it has shown the ability to reverse cachexia in rodents by inhibiting the ATP-ubiquitin-dependent proteolytic system. In Parkinson's disease models, Formoterol hemifumarate has been shown to rescue motor function deficits and nigrostriatal dopamine loss induced by lipopolysaccharide (LPS). With its clinical utility and efficacy in respiratory diseases, Formoterol hemifumarate is an essential tool for healthcare professionals and patients alike. Utilize this potent β2-adrenergic agonist to improve respiratory health and enhance overall well-being.