Latest Model Indirubin, Ahr Ligand (tbi1383) Family Size [iI8J3VaP]

Indirubin AhR Ligand (TBI1383): A Potent Natural AhR Agonist

Indirubin, also known as TBI1383, is a highly effective AhR (AhR ligand) that demonstrates remarkable potency, 10-fold greater than the endogenous agonist TCDD. This natural product has gained significant attention due to its ability to induce human AhR-dependent gene expression. Its unique molecular structure, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one, contributes to its efficacy. With a purity of over 98% and a formula weight of 262.30, Indirubin is a reliable choice for research and development.

Key Product Specifications

This premium AhR ligand is available in powder form, offering ease of handling and application. It boasts a high solubility in DMSO, up to 10 mg/ml, making it convenient for researchers to dissolve and dilute in aqueous buffers. With a CAS number of 479-41-4, Indirubin is easily identified and traceable. Its stability is exceptional, with a shelf life of ≥ 1 year at room temperature (RT), ensuring long-term storage without degradation.

Applications and Benefits of Indirubin AhR Ligand

Indirubin AhR Ligand (TBI1383) finds wide applications in various research fields. Its ability to inhibit CDKs and GSK-3β at low concentrations (IC50 = 50–100 nM and IC50 = 5-50 nM, respectively) makes it a valuable tool for studying cell cycle regulation and signaling pathways. Furthermore, Indirubin has been shown to ameliorate the effects of a high-fat diet in mice, break the inflammatory cycle in psoriasis models, inhibit angiogenesis, and induce autophagy and apoptosis in cancer cells. These properties make it an ideal candidate for research into inflammation, cancer, and metabolic diseases. Whether you are a researcher, scientist, or healthcare professional, Indirubin AhR Ligand offers a versatile and powerful tool for your studies.