Hard To Find Cd146 Monoclonal Antibody (p1h12), Novafluor™ Blue 610-70s Holiday Cheer Edition [B5FoERKA]

CD146 Monoclonal Antibody (P1H12)

The Hard To Find Cd146 Monoclonal Antibody (p1h12), Novafluor™ Blue 610-70s Holiday Cheer Edition [B5FoERKA], is a highly specialized reagent designed for research applications in immunology and oncology. This antibody recognizes CD146, also known as MUC18, s-endo, Endo-CAM, and Mel-CAM, a member of the Ig superfamily of proteins. The expression of CD146 is found on various cell types, including endothelial cells, bone marrow fibroblasts, and certain tumors, particularly melanoma. This antibody is a valuable tool for studying the role of CD146 in various biological processes and diseases.

Product Features and Specifications

The P1H12 antibody is specifically engineered for flow cytometric analysis, offering precise and reliable staining of CD146-expressing cells. It has been pre-titrated and tested for optimal performance with normal human peripheral blood cells and Human Umbilical Vein Cells (HUVEC). The antibody is highly glycosylated, with more than 50% of its mass derived from carbohydrates, which contributes to its unique binding properties. Additionally, the P1H12 antibody has been reported to crossreact with mouse, rabbit, and canine cells, making it a versatile tool for comparative studies.

Applications and Benefits

This monoclonal antibody is ideal for researchers seeking to investigate the presence and function of CD146 in various cellular contexts. Its applications extend to the study of mesenchymal stromal cells, endometrial stromal cells, and activated lymphocytes. The NovaFluor™ Blue 610-70S conjugate provides a bright and specific fluorescence signal, allowing for clear visualization of CD146-expressing cells. To enhance the staining process, the product is supplied with CellBlox Blocking Buffer, which helps to minimize background noise and improve signal-to-noise ratios. With the P1H12 antibody, researchers can confidently explore the complex biology of CD146 and its role in health and disease.