Thanksgiving Deal Pe Anti-mouse Cd366 (tim-3) Device [9bvjsgOn]

PE Anti-Mouse CD366 (Tim-3)

The PE Anti-Mouse CD366 (Tim-3) is a highly specialized monoclonal antibody designed for researchers studying immune responses and cellular interactions. This antibody targets the T cell immunoglobulin and mucin domain containing protein-3 (Tim-3), a transmembrane protein expressed predominantly on Th1 lymphocytes and CD11b⁺ macrophages. The Tim-3 protein plays a crucial role in modulating immune responses, particularly in the context of Th1-mediated immune responses and the promotion of immunological tolerance.

Product Features and Specifications

• Clone: RMT3-23
• Antibody Type: Monoclonal
• Reactivity: Mouse
• Format: PE (Phycoerythrin conjugated)
• Host: Rat
• Isotype: IgG2a, κ

The PE conjugation allows for fluorescence-activated cell sorting (FACS) and flow cytometry applications, making it an ideal tool for cell surface analysis. This product has been quality tested for flow cytometry (FC), ensuring reliable results in your experiments.

Practical Applications

The PE Anti-Mouse CD366 (Tim-3) is particularly useful in studying the role of Tim-3 in immune responses, especially in conditions like experimental autoimmune encephalomyelitis (EAE). Cells expressing Tim-3 are often found at high levels in the central nervous system (CNS) during the onset of EAE, a disease characterized by Th1-like cytokine secretion. By using this antibody, researchers can investigate how Tim-3 inhibits Th1-mediated immune responses and promotes immunological tolerance. The regulatory status of this product is RUO (Research Use Only), making it suitable for a wide range of research applications.