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PE/Dazzle™ 594 Anti-Human CD279 (PD-1)

The PE/Dazzle™ 594 Anti-Human CD279 (PD-1) is a highly specialized monoclonal antibody designed for the detection and analysis of human Programmed Cell Death 1 (PD-1), also known as CD279. This key molecule plays a crucial role in peripheral tolerance and autoimmune disease regulation. With its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region, CD279 is predominantly expressed on activated T cells, B cells, and myeloid cells, making it an essential target for research in immunology and oncology. This antibody offers a reliable tool for studying the interaction between CD279 and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), which are known to inhibit T cell proliferation and cytokine secretion.

Product Specifications and Benefits

The PE/Dazzle™ 594 conjugation provides exceptional fluorescence intensity and photostability, making it ideal for flow cytometry applications. The EH12.2H7 clone, derived from a mouse host, offers high specificity and affinity for human CD279. This monoclonal antibody is formatted in PE-Dazzle594, a bright and photostable dye that enhances the sensitivity and resolution of your experiments. Key features include:

Monoclonal antibody for human CD279 (PD-1)

Reactivity: Human

Format: PE-Dazzle594

Host: Mouse

Isotype: IgG1, κ

Applications and Target Audience

The PE/Dazzle™ 594 Anti-Human CD279 (PD-1) is a versatile tool for researchers in immunology, oncology, and related fields. Its applications span a wide range of experimental settings, including:

Flow cytometry analysis of T cells, B cells, and myeloid cells

Studying the role of PD-1 in immune regulation and autoimmune diseases

Investigating the interaction between PD-1 and its ligands in cancer immunotherapy

This product is particularly beneficial for researchers looking to gain deeper insights into the complex mechanisms of immune tolerance and cancer immunotherapy. With its high quality and reliable performance, the PE/Dazzle™ 594 Anti-Human CD279 (PD-1) is an essential addition to any research lab focused on the immune system and its diseases.