Clinically Tested Brilliant Violet 605™ Anti-human Cd45 2.0 Edition [NdhSO6Bm]

Brilliant Violet 605™ Anti-Human CD45

The Clinically Tested Brilliant Violet 605™ Anti-human Cd45 2.0 Edition [NdhSO6Bm], clone HI30, is a highly specialized monoclonal antibody designed for the detection of CD45, a crucial signaling molecule expressed on the plasma membranes of all hematopoietic cells except erythrocytes and platelets. This antibody offers exceptional specificity and sensitivity, making it an ideal tool for immunophenotyping and research applications.

• Highly Specific: The HI30 clone provides robust binding to CD45, ensuring accurate and reliable results.
• Wide Application Range: This antibody is suitable for flow cytometry, allowing for detailed analysis of hematopoietic cell populations.

Product Details

This monoclonal antibody is produced in mice and conjugated to Brilliant Violet 605™, a vibrant fluorescent dye that excites at 405 nm and emits at 605 nm. The antibody recognizes human CD45, a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. The following specifications highlight the product's quality and versatility:

• Host: Mouse
• Isotype: IgG1, κ
• Format: BV605
• Reactivity: Human

Applications and Benefits

The Clinically Tested Brilliant Violet 605™ Anti-human Cd45 2.0 Edition [NdhSO6Bm] is an invaluable tool for researchers studying hematopoiesis, immunology, and oncology. Its ability to dephosphorylate substrates involved in cell growth, differentiation, cell cycle, and oncogenic transformation makes it particularly useful in understanding complex cellular processes. The following scenarios illustrate the practical applications of this antibody:

• Flow Cytometry: Ideal for immunophenotyping and analysis of hematopoietic cell populations.
• Immunology Research: Useful for studying the role of CD45 in T and B cell signaling and activation.

By utilizing this antibody, researchers can gain deeper insights into the complexities of the immune system and its associated diseases.