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Introducing Alexa Fluor® 488 Anti-Vimentin

Alexa Fluor® 488 Anti-Vimentin is a powerful tool for researchers studying mesenchymal cells and various non-epithelial cells. This monoclonal antibody, Clone O91D3, is designed to specifically bind to vimentin, a class-III intermediate filament protein found in a wide range of cell types. Vimentin serves as a crucial marker for mesenchymal cells, helping to distinguish them from epithelial cells. This antibody is particularly useful in cancer research, where increased vimentin expression is often associated with epithelial-mesenchymal transition (EMT), a key process in tumor progression. With its high specificity and affinity, Alexa Fluor® 488 Anti-Vimentin offers reliable and consistent results across various experimental applications.

Product Features and Specifications

This antibody is produced in mice and conjugated with Alexa Fluor® 488, a vibrant and highly fluorescent dye that enhances signal detection. The format is monovalent IgG2a, κ, providing a robust and reliable immune response. Its human reactivity ensures compatibility with human cell lines and tissues, making it ideal for immunocytochemistry (ICC), immunofluorescence (IFC), and immunohistochemistry (IHC-P) applications. The product has been quality tested for ICC and verified for IHC-P, ensuring its versatility and reliability in different experimental settings. With its regulatory status as RUO (Research Use Only), this antibody is suitable for a wide range of research and diagnostic applications.

Applications and Benefits

Utilizing Alexa Fluor® 488 Anti-Vimentin offers numerous benefits for researchers. Its high specificity and affinity for vimentin enable precise identification and quantification of mesenchymal cells. This antibody is particularly valuable in studies of autoimmune diseases, such as Lupus and rheumatoid arthritis, where autoantibodies to vimentin are commonly detected. Additionally, its application in cancer research helps in understanding the complex process of EMT and its role in tumor progression. The combination of these features makes Alexa Fluor® 488 Anti-Vimentin an indispensable tool for researchers in cell biology, immunology, and oncology.