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APC Anti-Human Aiolos Antibody

The APC Anti-Human Aiolos Antibody is a highly specialized monoclonal antibody designed for researchers studying hematopoetic-specific transcriptional activation. This antibody targets Aiolos, also known as Ikaros family zinc finger 3 (IKZF3), a crucial 58kD zinc finger protein. Aiolos plays a pivotal role in the regulation of gene expression in B lymphocytes through chromatin remodeling and the formation of homodimers and heterodimers with other Ikaros family members. This antibody is a valuable tool for understanding the complex mechanisms involved in B cell development and function.

Product Specifications and Features

The APC Anti-Human Aiolos Antibody is produced by BioLegend, Inc., and is available in a convenient APC conjugate format. This antibody is derived from a mouse host and is of the IgG1, κ isotype. It is specifically reactive with human Aiolos, making it ideal for immunocytochemistry (ICC), immunofluorescence (IF), and flow cytometry (FC) applications. The antibody clone 14C4C97 has been quality tested for its performance in these techniques, ensuring reliable results in your research. Additionally, this product carries a regulatory status of RUO (Research Use Only), allowing for flexibility in its use in various research settings.

Applications and Benefits

The APC Anti-Human Aiolos Antibody is an essential resource for researchers investigating B cell biology and hematopoietic disorders. Its ability to detect Aiolos expression in B lymphocytes can aid in understanding the molecular mechanisms underlying diseases such as pre-B-acute lymphocytic leukemia (B-ALL). The antibody's versatile applications in ICC, IF, and FC make it a valuable addition to any laboratory toolkit. By using this antibody, researchers can gain deeper insights into the role of Aiolos in B cell development and the potential implications for disease diagnosis and treatment.