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APC/Fire™ 750 Anti-Human B7-H4

The APC/Fire™ 750 Anti-Human B7-H4 is a cutting-edge monoclonal antibody designed for the detection and analysis of B7-H4, also known as VTCN1, in human samples. This protein, a member of the B7 family, plays a crucial role in immune regulation and is associated with various carcinomas, including renal, gastric, breast, ovarian, and melanoma. With its ability to inhibit T cell proliferation, cytokine secretion, and cytotoxicity, B7-H4 expression is a significant biomarker for poor prognosis. Our antibody offers a powerful tool for researchers studying immune evasion and cancer progression.

Product Specifications and Features

The APC/Fire™ 750 Anti-Human B7-H4 clone MIH43 is a mouse monoclonal antibody with high specificity for human B7-H4. It is conjugated to APC-Fire 750, a highly sensitive fluorochrome that provides excellent signal-to-background ratios. The antibody format is IgG1, κ, and it has been quality tested for flow cytometry applications. Key features include its reactivity with human cells and its ability to detect B7-H4 expression on activated T cells, B cells, monocytes, and dendritic cells. This product is suitable for use in research and diagnostic settings where the analysis of B7-H4 is required.

Applications and Benefits

The APC/Fire™ 750 Anti-Human B7-H4 is an invaluable resource for researchers investigating the role of B7-H4 in immune response and cancer. Its use in flow cytometry allows for the precise quantification of B7-H4 expression, aiding in the identification of patients with poor prognosis. With its regulatory status as RUO (Research Use Only), this antibody is ideal for a wide range of applications, including clinical research, drug discovery, and diagnostic testing. By using this product, researchers can gain deeper insights into the complex mechanisms of cancer and develop new strategies for treatment and diagnosis.