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APC Anti-Mouse CD49b Antibody

The APC Anti-Mouse CD49b Antibody is a highly specialized tool designed for researchers studying the integrin family, particularly the α2 integrin, also known as CD49b. This monoclonal antibody offers exceptional specificity and sensitivity, making it an invaluable asset for various immunological applications. With its ability to bind to CD49b, this antibody facilitates the detection and analysis of this important protein, which is expressed on a wide range of cell types including NK cells, T cells, and platelets.

Product Features and Specifications

The APC Anti-Mouse CD49b Antibody, clone HMα2, is produced by Armenian Hamster and conjugated to APC, a fluorochrome that emits fluorescence at longer wavelengths, allowing for simultaneous staining with other fluorescent markers. This antibody is of the IgG isotype and has been quality tested for flow cytometry (FC) applications. Its reactivity is exclusive to mouse cells, making it a powerful tool for researchers studying mouse models or samples. The following features highlight the advantages of this product:

• High specificity and sensitivity: Ensures accurate detection of CD49b expression.
• APC conjugation: Allows for simultaneous staining with other markers for comprehensive analysis.

Practical Applications

The APC Anti-Mouse CD49b Antibody is a versatile tool with a wide range of applications in immunology and cellular biology. Its ability to block CD49b-mediated interactions with collagen makes it particularly useful for studies involving lymphocyte activation and adhesion. Additionally, this antibody has been shown to block staining of splenic NK cells by the monoclonal antibody DX5, offering a valuable tool for the characterization of NK cell subsets. The following applications highlight the practical value of this product:

• Flow cytometry: Ideal for detecting and analyzing CD49b expression on various cell types.
• Immunophenotyping: Useful for identifying and characterizing NK cells and other cell subsets.