On Sale Apc Anti-mouse Il-17rb Kit [kEj3APLs]

APC Anti-Mouse IL-17RB Antibody

The APC Anti-Mouse IL-17RB Antibody is a highly specialized monoclonal antibody designed for the detection and analysis of IL-17RB, also known as IL17RH1, in mouse samples. This antibody is a valuable tool for researchers studying the role of IL-17RB in various biological processes, particularly in autoimmune diseases such as rheumatoid arthritis and asthma. With its unique intracellular signaling molecule, SEFIR, and expression patterns similar to fibroblast growth factor genes and IL-17R, IL-17RB plays a crucial role in immune responses.

Product Specifications

The APC Anti-Mouse IL-17RB Antibody, clone 9B10, is produced using rat immunoglobulin G2a, κ isotype. This antibody is formatted in APC conjugation, providing a strong and vibrant signal for flow cytometry applications. Its reactivity is specific to mouse samples, making it ideal for use in various research settings. Key features of this antibody include:

• Host Species: Rat
• Isotype: IgG2a, κ
• Applications: Flow Cytometry

Applications and Benefits

The APC Anti-Mouse IL-17RB Antibody is a versatile reagent for investigating the expression and function of IL-17RB in various cell types, including iNKT cells, innate lymphoid cells (ILC), and Th2 cells. It binds specifically to IL-17B and IL-17E (IL-25), with a higher affinity for IL-25 than IL-17B. This antibody is particularly useful for studying the interaction between IL-17RB and IL-25, which triggers NF-kB-mediated IL-8 production through TRAF6 and Act1. By using this antibody, researchers can gain valuable insights into the complex signaling pathways involved in autoimmune diseases and other inflammatory conditions.