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APC Anti-Mouse TIGIT (Vstm3)

The APC Anti-Mouse TIGIT (Vstm3) is a highly specialized monoclonal antibody designed for research purposes. This antibody targets the T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3). TIGIT plays a crucial role in immune regulation, expressed on various immune cells including activated T cells, follicular T helper cells, memory cells, regulatory T cells, and NK cells. Its binding partners, CD155 (PVR) and CD112 (PVRL2), make it a key player in the negative regulation of NK and T cell activation. The product is formatted in APC, ensuring optimal staining for flow cytometry applications.

Product Specifications

The APC Anti-Mouse TIGIT (Vstm3) is produced through a mouse monoclonal antibody technique, cloned as 1G9. It is of the IgG1, κ isotype, and is suitable for use in flow cytometry. This antibody has been quality tested for its functionality and specificity, ensuring reliable results in your research. The product is supplied by BioLegend, Inc., a trusted manufacturer in the field of immunology research. Below are the key features and specifications of the APC Anti-Mouse TIGIT (Vstm3):

• Clone: 1G9
• Antibody Type: Monoclonal
• Reactivity: Mouse
• Format: APC
• Host: Mouse
• Isotype: IgG1, κ

Applications and Benefits

The APC Anti-Mouse TIGIT (Vstm3) is a valuable tool for researchers studying immune regulation and cell signaling. Its ability to engage TIGIT on various immune cells makes it ideal for investigating the role of TIGIT in autoimmune diseases, where mice deficient for TIGIT are more susceptible. The antibody's binding to TIGIT can lead to the differentiation of dendritic cells into a tolerogenic phenotype, which is crucial for understanding immune tolerance. With its wide range of applications in flow cytometry, this antibody is suitable for both basic research and clinical studies. The benefits of using the APC Anti-Mouse TIGIT (Vstm3) include:

• Enhanced understanding of immune regulation
• Improved research outcomes in autoimmune disease studies
• High specificity and reliability in flow cytometry applications