Complete Rabbit Anti Hmgb1 Polyclonal Affinity Purified (pbs With 0.02% Sodium Azide, 1% Bsa And 50% Glycerol, Ph7.4) (western Blot,ihc,immunofluorescence) Holiday Cheer Edition [PYRewMkm]

Complete Rabbit Anti Hmgb1 Polyclonal Affinity Purified (pbs With 0.02% Sodium Azide, 1% Bsa And 50% Glycerol, Ph7.4) (western Blot,ihc,immunofluorescence) Holiday Cheer Edition [PYRewMkm] from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 This antibody has been affinity purified.

More Details:

• Host: Rabbit
• Species: Human,Mouse,Rat
• Target: HMGB1
• Clonality: Polyclonal
• Purity: Affinity Purified
• Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse HMGB1
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

This product can be used in analytical tools such as Western Blot,IHC,Immunofluorescence.

At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

For research use only.