Fast Delivery Rabbit Anti Human Adam17 Polyclonal Affinity Purified (pbs With 0.02% Sodium Azide, 50% Glycerol, Ph7.3) (ihc) Limited Time 70% Off [qj1Y4EXM]

Fast Delivery Rabbit Anti Human Adam17 Polyclonal Affinity Purified (pbs With 0.02% Sodium Azide, 50% Glycerol, Ph7.3) (ihc) Limited Time 70% Off [qj1Y4EXM] from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 50% glycerol, pH7.3 This antibody has been purified using Affinity Purified.

More Details:

• Host: Rabbit
• Species: Human,Mouse,Rat
• Target: ADAM17
• Clonality: Polyclonal
• Purity: Affinity Purified
• Immunogen: A synthetic peptide of human ADAM17 (NP_003174.3).
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

This product can be used in analytical tools such as IHC.

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For research use only.