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Recombinant Rat Cystatin C Protein (His Tag)

Introducing our high-quality Recombinant Rat Cystatin C Protein (His Tag), a reliable and efficient tool for research in renal function assessment. This protein, also known as Cystatin-3 (CST3), is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells. It has gained significant attention in the field of medical research due to its potential as a replacement for serum creatinine in assessing kidney function. The protein's unique properties make it an invaluable asset for researchers seeking accurate and reliable measurements of renal health.

Product Specifications and Properties

Our Recombinant Rat Cystatin C Protein (His Tag) is produced in HEK293 cells, ensuring high purity and consistent quality. The protein has a calculated molecular weight of 14.7 kDa and an observed molecular weight of 18-25 kDa. It is tagged with a C-His tag for easy detection and purification. The protein is also bio-active, although it has not been validated for activity. Key properties include a purity of >95% as determined by reducing SDS-PAGE and an endotoxin level of <1.0 EU per μg of the protein. This product is lyophilized from a sterile solution containing 20mM HEPES, 150mM NaCl, pH 7.0, with added protectants such as trehalose, mannitol, and Tween 80.

Practical Applications and Benefits

The Recombinant Rat Cystatin C Protein (His Tag) is an essential tool for researchers studying renal function and kidney disease. Its potential use in detecting small reductions in glomerular filtration rate makes it particularly valuable in clinical settings where creatinine production and muscle mass can impair the accuracy of creatinine-based assessments. This protein has shown better diagnostic accuracy than serum creatinine in distinguishing normal from impaired kidney function. Its unique properties also make it a promising marker for early detection of various conditions, including early atherosclerosis, Alzheimer's dementia, and other neurodegenerative diseases. By using our Recombinant Rat Cystatin C Protein (His Tag), researchers can advance their studies and contribute to the development of more effective diagnostic tools and treatments for renal disorders.