Compact Recombinant Human B7-h4/vtcn1 Protein (mfc Tag) Pro Version [COyD4wX0]

High-Quality Recombinant Human B7-H4 Protein

Discover the superior quality of our Compact Recombinant Human B7-h4/vtcn1 Protein (mfc Tag) Pro Version [COyD4wX0], a meticulously engineered product designed for research and diagnostic applications. This protein is derived from HEK293 cells, ensuring high purity and reliability. With a calculated molecular weight of 51.9 kDa and observed molecular weight ranging from 66-105 kDa, it offers a wide range of applications in cellular research and immunology studies.

Comprehensive Product Specifications

Our B7-H4 protein is characterized by its C-mFc tag, providing ease of detection and purification. It is available in a lyophilized powder form, which is shipped with ice packs to ensure freshness. This product is >95% pure, as determined by reducing SDS-PAGE, and contains less than 1.0 EU per μg of protein as measured by the LAL method. Additionally, the protein is formulated with 5%-8% trehalose, mannitol, and 0.01% Tween 80 as protectants to maintain stability and activity.

Extensive Applications in Research

The Compact Recombinant Human B7-h4/vtcn1 Protein (mfc Tag) Pro Version [COyD4wX0] is a valuable tool for investigating the role of B7-H4 in immune regulation and tumor biology. B7-H4 is known to negatively regulate T-cell-mediated immune responses by inhibiting T-cell activation, proliferation, cytokine production, and cytotoxicity. Its expression on tumor macrophages, along with regulatory T-cells (Treg), plays a crucial role in suppressing tumor-associated antigen-specific T-cell immunity. This protein can be used to study the mechanisms of immune evasion and tumor progression, offering new insights into potential therapeutic targets.