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Recombinant Human FGF-18 Protein (N-His) (Active)

Discover the power of recombinant human FGF-18 protein (N-His) (active) in your research. This high-quality, active protein is produced through recombinant technology, offering unparalleled purity and bio-activity. With its ability to induce 3T3 cell proliferation and its specific activity exceeding 5 x 10⁵ IU/mg, this protein is a valuable tool for studying fibroblast growth factors and their role in various biological processes.

Product Properties and Specifications

Our recombinant human FGF-18 protein (N-His) (active) is characterized by its exceptional purity, exceeding 98% as determined by reducing SDS-PAGE. It boasts a calculated molecular weight of 21.1 kDa and an observed molecular weight of 20 kDa. This protein is tagged with a C-His tag, ensuring easy detection and purification. Key specifications include a species origin of human, expression host of E. coli, and a sequence spanning from Ala 27 to Arg 199. Its bio-activity is demonstrated by its ability to induce 3T3 cell proliferation with an ED₅₀ of 1.3-2.0 ng/mL.

Applications and Benefits

Recombinant human FGF-18 protein (N-His) (active) is a versatile tool for researchers studying fibroblast growth factors and their impact on cell proliferation, differentiation, and tissue repair. This protein is particularly useful in understanding the role of FGF18 in embryonic development, cell growth, morphogenesis, and tumor growth. Its selective ligand activity for FGFR3 in limb bud mesenchymal cells makes it a valuable resource for exploring the molecular mechanisms behind bone development and cartilage matrix production. With its ease of use, high purity, and active form, this protein is an essential component of any research lab focused on fibroblast growth factors and their biological functions.