Overstock Deal Recombinant Mouse Icos Ligand/icosl Protein (his & Fc Tag)(active) With Warranty [chSErfiH]

Overstock Deal Recombinant Mouse Icos Ligand/icosl Protein (his & Fc Tag)(active) With Warranty [chSErfiH]

The Overstock Deal Recombinant Mouse Icos Ligand/icosl Protein (his & Fc Tag)(active) With Warranty [chSErfiH] is a highly pure and biologically active protein derived from HEK293 cells. This protein is designed with a C-His-Fc tag and has a calculated molecular weight of 54.3 kDa. It is a crucial component of the B7 family of co-stimulatory molecules, playing a pivotal role in T cell activation and immune response regulation. Key features include its ability to bind to ICOS on activated T cells, delivering a positive costimulatory signal for optimal T cell function.

Product Properties and Specifications

This recombinant protein is offered at a purity of greater than 95%, as determined by reducing SDS-PAGE. It is also endotoxin-free, with less than 1.0 EU per μg of the protein as determined by the LAL method. The protein is lyophilized from sterile PBS, pH 7.4, and contains stabilizers such as trehalose, mannitol, and Tween 80. It is shipped with ice packs to ensure its stability during transportation. The observed molecular weight of the protein ranges from 75-85 kDa, which is slightly higher than the calculated molecular weight due to post-translational modifications.

Applications and Benefits

The Overstock Deal Recombinant Mouse Icos Ligand/icosl Protein (his & Fc Tag)(active) With Warranty [chSErfiH] is an essential tool for researchers studying T cell activation and immune response regulation. It can be used in various applications, including the study of B7-H2-dependent signaling in proliferative responses and the interaction between the CD28/B7 and ICOS/B7-H2 pathways. This protein is suitable for use in in vitro assays, including ELISA, immunoprecipitation, and Western blotting. By using this product, researchers can gain deeper insights into the mechanisms of T cell activation and immune response regulation, leading to potential advancements in the treatment of immune-related diseases. The high purity and activity of this protein make it a reliable and efficient choice for research in immunology and related fields.